ncRNA name | THOR |
ncRNA Category | lncRNA |
ID | 100506797 |
Ensembl | ENSG00000226856 |
Synonyms | THORLNC |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB samples; human RB cell line WERI‑Rb1 and Y79; human retinal epithelial cell line ARPE-19 |
Methods | RT-PCR, Western blot, immunoprecipitation, RNA pull down assay, MTT assay, flow cytometry, transwell assay, xenograft |
Expression pattern | up-regulated |
Functional description | LncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells through up-regulating c-myc expression via enhancing its combination with TGF2BP1 protein. |
PubMed ID | 30119193 |
Year | 2018 |
Title | LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein. |
Drug-related ncRNA | NO |
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